| ncRNA name | TXNIP3 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | rat retinal capillary pericytes TR-rPCT1; rat retina capillary endothelial cell line TR-iBRB2 |
| Methods | qRT-PCR, SDS-PAGE, Western blot, immunohistochemistry, gel-shift assay |
| Expression pattern | associated |
| Functional description | Treatment of TR-rPCT1 with NAC or an inhibition of TXNIP by AzaS or siTXNIP3 each reduces HG-induced ROS, caspase-3 activation and DNA damage demonstrating that TXNIP up-regulation under chronic hyperglycemia is critically involved in cellular oxidative stress, DNA damage and retinal pericyte apoptosis. |
| PubMed ID | 23353834 |
| Year | 2013 |
| Title | Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.